Research

A Better Future for ChildrenActive Research Projects

ABC PICU (Age of Blood in Children in Pediatric Intensive Care Units)

  • ClinicalTrials.gov identifier: NCT01977547
  • Co-PI: Leslie Avery, Peter Pelletier
    Secondary Investigators: Charlene Leonard, Lindsay Sikora
  • Multicenter (>40 children’s hospitals) randomized clinical trial comparing the clinical consequences of RBC storage duration in 1538 critically ill children.
  • Resultant publications: pending completion of the trial

COBO2 (Continuous vs BOlus Nasogastric Feeding in Mechanically Ventilated Pediatric Patients 2

  • ClinicalTrials.gov identifier: NCT02566070
  • Co-PI: Torrey Baines, Charlene Leonard
  • Multicenter (7 children’s hospitals) randomized clinical trial comparing continuous versus bolus gastric feeding modes for timing and delivery of prescribed energy (kcal/kg/day) and protein (g/kg/day) for over 200 mechanically ventilated children 1 month through 12 years of age.
  • Resultant publications: pending completion of the trial

Continuous albuterol (FM vs HFNC)

  • Co-PI: Nekaiya Jacobs, Jennifer Munoz
  • Single center observational study comparing outcomes of high flow nasal cannula and face mask for continuous albuterol delivery and association with length of stay, asthma scores, and need for escalation of therapy
  • Resultant publications: pending completion of the trial

Pediatric TBI Repository

  • PI: Jennifer Munoz
  • The overall goal of this study is to create a pediatric TBI biorepository that will serve as a platform for a systematic, multimodal assessment of severity and outcome at the University of Florida.
  • Resultant publications: pending

Autoimmune CNS

  • PI: Jennifer Munoz
  • Identification of autoimmune central nervous system diseases via flow cytometry.
  • Resultant publications: pending

PERSEVERE (Genomic analysis of pediatric systemic inflammatory response syndrome)

  • PI: Ravi Samraj
  • Multicenter study including patients 1 months to 10 years of age admitted to the PICU with SIRS or sepsis. The purpose of the study is to determine if outcomes in pediatric sepsis are influence by any specific genetic makeup of the individual.
  • Resultant publications: pending completion of the study

Thenar tissue oxygenation (StO2): A non-invasive surrogate marker for central venous oxygen saturation.

  • PI: Ravi Samraj
  • Study comparing thenar tissue oxygenation device with traditional central venous oxygen saturations in critically ill children.
  • Resultant publications: pending completion of the study

NPO/NIV (Nutritional practices and outcomes in non-invasive ventilation)

  • PI: Charlene Leonard
  • Multicenter (>80 children’s hospitals) period prevalence study evaluation nutiritional practices and patient outcomes across global regions for enteral and parenteral nutrition for infants and children initiated on NIV (BiPAP, CPAP, HFNC) for six 7 day study periods over 2017 and 2018.
  • Resultant publications: pending completion of the study

PICU/PCICU Delirium

  • Co-PI: Molly McGetrick, Jennifer Munoz
  • Single center, CAPD scoring for up to 7 days on most PICU and PCICU patients to define prevalence of delirium in our patient population.
  • Resultant publications: pending completion of the study

MATIC (Massive Transfusion Epidemiology and Outcomes Study in Children)

  • Co-PI: Leslie Avery, Peter Pelletier
  • Multicenter prospective, observational study designed to investigate massive transfusion protocols and damage control resuscitation therapies in pediatric critical care.
  • Resultant publications: pending completion of the study