Research

A Better Future for ChildrenActive Research Projects

ABC PICU (Age of Blood in Children in Pediatric Intensive Care Units)

  • ClinicalTrials.gov identifier: NCT01977547
  • Co-PI: Leslie Avery, Peter Pelletier
    Secondary Investigators: Charlene Leonard, Lindsay Sikora
  • Multicenter (>40 children’s hospitals) randomized clinical trial comparing the clinical consequences of RBC storage duration in 1538 critically ill children.
  • Resultant publications: pending completion of the trial

COBO2 (Continuous vs BOlus Nasogastric Feeding in Mechanically Ventilated Pediatric Patients 2

Continuous Albuterol (FM vs HFNC)

  • Co-PI: Nekaiya Jacobs, Jennifer Munoz
  • Single center observational study comparing outcomes of high flow nasal cannula and face mask for continuous albuterol delivery and association with length of stay, asthma scores, and need for escalation of therapy
  • Critical Care Medicine – Article

Development and Validation of a Nutrition Screening Tool for Critically Ill Children

  • PI: Charlene Leonard
  • Multi-center phase II validation of a novel screening tool for malnutrition in critically ill children.
  • Resultant publications: pending completion of trial

DOSE trial: Dexmedetomidine Opioid Sparing Effect in Mechanically Ventilated Children

  • PI: Jennifer Munoz
  • Multi-center RCT.
  • Resultant publications: pending completion of trial

LVK (LongVentKids study): Prolonged Mechanical Ventilation in Pediatric Intensive Care

  • PI: Elizabeth Macari
  • Multi-center/PALISI period prevalence study about long term mechanical ventilation.
  • Resultant publications: pending completion of trial

Pediatric TBI Repository

  • PI: Jennifer Munoz
  • The overall goal of this study is to create a pediatric TBI biorepository that will serve as a platform for a systematic, multimodal assessment of severity and outcome at the University of Florida.
  • Resultant publications: pending

T-CF Testing for Autoimmune Disease

  • PI: Jennifer Munoz
  • Identification of autoimmune central nervous system diseases via flow cytometry.
  • Resultant publications: pending

PERSEVERE (Genomic analysis of pediatric systemic inflammatory response syndrome)

  • PI: Torrey Baines
  • Multicenter study including patients 1 months to 10 years of age admitted to the PICU with SIRS or sepsis. The purpose of the study is to determine if outcomes in pediatric sepsis are influence by any specific genetic makeup of the individual.
  • Resultant publications: pending completion of the study

Thenar tissue oxygenation (StO2): A non-invasive surrogate marker for central venous oxygen saturation.

  • PI: Ravi Samraj
  • Study comparing thenar tissue oxygenation device with traditional central venous oxygen saturations in critically ill children.
  • Resultant publications: pending completion of the study

NPO/NIV (Nutritional practices and outcomes in non-invasive ventilation)

  • PI: Charlene Leonard
  • Multicenter (>80 children’s hospitals) period prevalence study evaluation nutiritional practices and patient outcomes across global regions for enteral and parenteral nutrition for infants and children initiated on NIV (BiPAP, CPAP, HFNC) for six 7 day study periods over 2017 and 2018.
  • Resultant publications: pending completion of the study

PICU/PCICU Delirium

  • Co-PI: Molly McGetrick, Jennifer Munoz
  • Single center, CAPD scoring for up to 7 days on most PICU and PCICU patients to define prevalence of delirium in our patient population.
  • Resultant publications: pending completion of the study

MATIC (Massive Transfusion Epidemiology and Outcomes Study in Children)

  • Co-PI: Leslie Avery, Peter Pelletier
  • Multicenter prospective, observational study designed to investigate massive transfusion protocols and damage control resuscitation therapies in pediatric critical care.
  • Resultant publications: pending completion of the study

PROSpect (PRone and OScillation PEdiatric Clinical Trial)

  • PI: Leslie Avery
  • Multicenter (~50 PICUs) 2×2 factorial, response adaptive randomized clinical trial of supine/prone positioning and CMV/HFOV for pediatric patients with severe pARDS.
  • Resultant publications: pending completion of trial

Peds PRES

  • PI: Charlene Leonard
  • Sub-I: Manuel Viamonte
  • Large case series of pediatric patients with hypertensive encephalopathy aiming to better describe risk factors and correlations.

Thenar Tissue Oxygenation for Pediatric Sepsis

  • PI: Lara Nicolas
  • Sub-I: Mai Miyaji
  • Study examining vascular occlusion test and outcomes in pediatric sepsis.