Clinical Course Comparison of Children with Acute Respiratory Failure Secondary to COVID-19 and Viral Infection compared to Viral Infection Alone
Multicentric chart review study
PI: Krystyn Linville
Hemodynamic profile and efficacy on ICP management of ketamine vs propofol or midazolam for children with severe TBI
Multicentric chart review study.
PI: Charlene Pringle, CPNP/AC-PC, FCCM (Joy fellowship project)
PERSEVERE
Genomic analysis of pediatric systemic inflammatory response syndrome
Site PI: Torrey Baines, MD
Publications:
- Atreya, M. R., Cvijanovich, N. Z., Fitzgerald, J. C., Weiss, S. L., Bigham, M. T., Jain, P. N., Schwarz, A. J., Lutfi, R., Nowak, J., Allen, G. L., Thomas, N. J., Grunwell, J. R., Baines, T., Quasney, M., Haileselassie, B., Alder, M. N., Goldstein, S. L., & Stanski, N. L. (2023). Prognostic and predictive value of endothelial dysfunction biomarkers in sepsis-associated acute kidney injury: risk-stratified analysis from a prospective observational cohort of pediatric septic shock. Critical care (London, England), 27(1), 260. https://doi.org/10.1186/s13054-023-04554-y
- Atreya, M. R., Bennett, T. D., Geva, A., Faustino, E. V. S., Rogerson, C. M., Lutfi, R., Cvijanovich, N. Z., Bigham, M. T., Nowak, J., Schwarz, A. J., Baines, T., Haileselassie, B., Thomas, N. J., Luo, Y., Sanchez-Pinto, L. N., & Novel Data-Driven Sepsis Phenotypes in Children Study and the Genomics of Pediatric Septic Shock Investigators. (2023). External validation and biomarker assessment of a high-risk, data-driven pediatric sepsis phenotype characterized by persistent hypoxemia, encephalopathy, and shock. Research square, rs.3.rs-3216613. https://doi.org/10.21203/rs.3.rs-3216613/v1
- Wong, H. R., Caldwell, J. T., Cvijanovich, N. Z., Weiss, S. L., Fitzgerald, J. C., Bigham, M. T., Jain, P. N., Schwarz, A., Lutfi, R., Nowak, J., Allen, G. L., Thomas, N. J., Grunwell, J. R., Baines, T., Quasney, M., Haileselassie, B., & Lindsell, C. J. (2019). Prospective clinical testing and experimental validation of the Pediatric Sepsis Biomarker Risk Model. Science translational medicine, 11(518), eaax9000. https://doi.org/10.1126/scitranslmed.aax9000
- Atreya, M. R., Cvijanovich, N. Z., Fitzgerald, J. C., Weiss, S. L., Bigham, M. T., Jain, P. N., Schwarz, A. J., Lutfi, R., Nowak, J., Allen, G. L., Thomas, N. J., Grunwell, J. R., Baines, T., Quasney, M., Haileselassie, B., Alder, M. N., Lahni, P., Ripberger, S., Ekunwe, A., Campbell, K. R., … Standage, S. W. (2023). Detrimental effects of PCSK9 loss-of-function in the pediatric host response to sepsis are mediated through independent influence on Angiopoietin-1. Critical care (London, England), 27(1), 250. https://doi.org/10.1186/s13054-023-04535-1
- Atreya, M. R., Cvijanovich, N. Z., Fitzgerald, J. C., Weiss, S. L., Bigham, M. T., Jain, P. N., Schwarz, A. J., Lutfi, R., Nowak, J., Thomas, N. J., Quasney, M., Haileselassie, B., Baines, T. D., Zingarelli, B., & Genomics of Pediatric Septic Shock Investigators (2023). SERUM SOLUBLE ENDOGLIN IN PEDIATRIC SEPTIC SHOCK-ASSOCIATED MULTIPLE ORGAN DYSFUNCTION SYNDROME. Shock (Augusta, Ga.), 60(3), 379–384. https://doi.org/10.1097/SHK.0000000000002183
- Stanski, N. L., Stenson, E. K., Cvijanovich, N. Z., Weiss, S. L., Fitzgerald, J. C., Bigham, M. T., Jain, P. N., Schwarz, A., Lutfi, R., Nowak, J., Allen, G. L., Thomas, N. J., Grunwell, J. R., Baines, T., Quasney, M., Haileselassie, B., & Wong, H. R. (2020). PERSEVERE Biomarkers Predict Severe Acute Kidney Injury and Renal Recovery in Pediatric Septic Shock. American journal of respiratory and critical care medicine, 201(7), 848–855. https://doi.org/10.1164/rccm.201911-2187OC
- Atreya, M. R., Cvijanovich, N. Z., Fitzgerald, J. C., Weiss, S. L., Bigham, M. T., Jain, P. N., Schwarz, A. J., Lutfi, R., Nowak, J., Allen, G. L., Thomas, N. J., Grunwell, J. R., Baines, T., Quasney, M., Haileselassie, B., Lindsell, C. J., Alder, M. N., & Wong, H. R. (2022). Integrated PERSEVERE and endothelial biomarker risk model predicts death and persistent MODS in pediatric septic shock: a secondary analysis of a prospective observational study. Critical care (London, England), 26(1), 210. https://doi.org/10.1186/s13054-022-04070-5
- Stanski, N. L., Cvijanovich, N. Z., Fitzgerald, J. C., Bigham, M. T., Wong, H. R., & Genomics of Pediatric Septic Shock Investigators (2020). Severe acute kidney injury is independently associated with mortality in children with septic shock. Intensive care medicine, 46(5), 1050–1051. https://doi.org/10.1007/s00134-020-05940-8
- Atreya, M. R., Piraino, G., Cvijanovich, N. Z., Fitzgerald, J. C., Weiss, S. L., Bigham, M. T., Jain, P. N., Schwarz, A. J., Lutfi, R., Nowak, J., Thomas, N. J., Baines, T., Haileselassie, B., & Zingarelli, B. (2023). Serum Humanin in Pediatric Septic Shock Associated Multiple Organ Dysfunction Syndrome. Shock (Augusta, Ga.), 10.1097/SHK.0000000000002266. Advance online publication. https://doi.org/10.1097/SHK.0000000000002266
Safety of extended propofol infusion in critically ill pediatric patients
Multicentric chart review study exploring safety of propofol infusions greater than 48 hours duration
PI: Charlene Pringle, CPNP/AC-PC, FCCM (Moas fellowship project)
Publications:
- Moas, D., Aydin, E. Y., Irazuzta, J., Filipp, S., Guthrie, K. K., Manasco, K., & Pringle, C. (2024). Safety of Extended Propofol Infusions in Critically Ill Pediatric Patients. Cureus, 16(5), e59948. https://doi.org/10.7759/cureus.59948
Post-extubation dysphagia in children after mechanical ventilatory support
PI: Emily Plowman and Desiree Machado (Wang fellow project)
Death One Hour After Terminal Extubation (DONATE) Study
PI: Charlene Pringle, CPNP/AC-PC, FCCM
Publications:
- Tripathi, S., Laksana, E., McCrory, M. C., Hsu, S., Zhou, A. X., Burkiewicz, K., Ledbetter, D. R., Aczon, M. D., Shah, S., Siegel, L., Fainberg, N., Morrow, K. R., Avesar, M., Chandnani, H. K., Shah, J., Pringle, C., & Winter, M. C. (2023). Analgesia and Sedation at Terminal Extubation: A Secondary Analysis From Death One Hour After Terminal Extubation Study Data. Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies, 24(6), 463–472. https://doi.org/10.1097/PCC.0000000000003209
- Pringle, C. P., Filipp, S. L., Morrison, W. E., Fainberg, N. A., Aczon, M. D., Avesar, M., Burkiewicz, K. F., Chandnani, H. K., Hsu, S. C., Laksana, E., Ledbetter, D. R., McCrory, M. C., Morrow, K. R., Noguchi, A. E., O’Brien, C. E., Ojha, A., Ross, P. A., Shah, S., Shah, J. K., Siegel, L. B., … Winter, M. C. (2023). Ventilator Weaning and Terminal Extubation: Withdrawal of Life-Sustaining Therapy in Children. Secondary Analysis of the Death One Hour After Terminal Extubation Study. Critical care medicine, 10.1097/CCM.0000000000006101. Advance online publication. https://doi.org/10.1097/CCM.0000000000006101
pBDCA (Validation of the Brain Death after out of hospital Cardiac Arrest score in children).
PI: Charlene Pringle, CPNP/AC-PC, FCCM
Publications:
- Henry, M., Filipp, S. L., Aydin, E. Y., Chiriboga, N., Zelinka, K., Smith, L. E., Gurka, M. J., Irazuzta, J., Fonseca, Y., Winter, M. C., Pringle, C., & Pediatric Acute Lung Injury and Sepsis Investigators (PALISI) Network (2023). Multicentric validation of a prognostic tool for predicting brain death following out-of-hospital cardiac arrest in children. Resuscitation, 185, 109727. https://doi.org/10.1016/j.resuscitation.2023.109727
Incidence of air leak syndrome in SARS-CoV-2 in pediatrics
PI: Charlene Pringle, CPNP/AC-PC, FCCM (Cardenas FELLOWSHIP PROJECT)
Publications:
- Cardenas, J., Cardenas, J. M., Garber, M., & Irazuzta, J. (2023). Incidence of Air Leak Syndrome in Pediatric Patients With SARS-COV-2 Pneumonia and Respiratory Failure: A Single-Center Retrospective Study. Cureus, 15(8), e43329. https://doi.org/10.7759/cureus.43329
Clinical changes in bronchiolitis after easing COVID-19 precautions
PI: Leslie Avery, MD (Cardenas fellowship project)
Publications:
- Cardenas, J., Pringle, C., Filipp, S. L., Gurka, M. J., Ryan, K. A., & Avery, K. L. (2022). Changes in Critical Bronchiolitis After COVID-19 Lockdown. Cureus, 14(5), e25064. https://doi.org/10.7759/cureus.25064
Tethered liquid perfluorocarbon (TLP) surface coating for ECMO tubing, In-vitro model using human blood
PI: Giles Peek (Vazquez-Colon fellow project)
High-Fidelity Simulation Training for Parents of Medically Complex Children
Single-center, non-randomized prospective trial implementing simulation training for parents who will be discharged from the PICU with a child with a new tracheostomy.
PI: William Bortcosh
Peds PRES
Large case series of pediatric patients with hypertensive encephalopathy aiming to better describe risk factors and correlations.
PI: Charlene Pringle, CPNP/AC-PC, FCCM | Sub-I: Manuel Viamonte
Publications:
- Pringle, C., Portwood, K., Viamonte, M. A., & Rajderkar, D. (2022). Imaging Findings in Neonatal and Pediatric Posterior Reversible Encephalopathy Syndrome (PRES) Differ From Adults. Pediatric neurology, 135, 6–11. https://doi.org/10.1016/j.pediatrneurol.2022.06.022
ABC PICU (Age of Blood in Children in Pediatric Intensive Care Units)
Multicenter (>40 children’s hospitals) randomized clinical trial comparing the clinical consequences of RBC storage duration in 1538 critically ill children.
CO-PI: Leslie Avery, MD; Peter Pelletier, MD
Publications:
- Spinella, P. C., Tucci, M., Fergusson, D. A., Lacroix, J., Hébert, P. C., Leteurtre, S., Schechtman, K. B., Doctor, A., Berg, R. A., Bockelmann, T., Caro, J. J., Chiusolo, F., Clayton, L., Cholette, J. M., Guerra, G. G., Josephson, C. D., Menon, K., Muszynski, J. A., Nellis, M. E., Sarpal, A., … ABC-PICU Investigators, the Canadian Critical Care Trials Group, the Pediatric Acute Lung Injury and Sepsis Investigators Network, the BloodNet Pediatric Critical Care Blood Research Network, and the Groupe Francophone de Réanimation et Urgences P (2019). Effect of Fresh vs Standard-issue Red Blood Cell Transfusions on Multiple Organ Dysfunction Syndrome in Critically Ill Pediatric Patients: A Randomized Clinical Trial. JAMA, 322(22), 2179–2190. https://doi.org/10.1001/jama.2019.17478
- Traube, C., Tucci, M., Nellis, M. E., Avery, K. L., McQuillen, P. S., Fitzgerald, J. C., Muszynski, J. A., Cholette, J. M., Schwarz, A. J., Stalets, E. L., Quaid, M. A., Hanson, S. J., Lacroix, J., Reeder, R. W., Spinella, P. C., & Transfusion-Associated Delirium ABC-PICU Study Group (2022). Transfusion-Associated Delirium in Children: No Difference Between Short Storage Versus Standard Issue RBCs. Critical care medicine, 50(2), 173–182. https://doi.org/10.1097/CCM.0000000000005393
COBO2 (Continuous vs BOlus Nasogastric Feeding in Mechanically Ventilated Pediatric Patients 2
Multicenter (7 children’s hospitals) randomized clinical trial comparing continuous versus bolus gastric feeding modes for timing and delivery of prescribed energy (kcal/kg/day) and protein (g/kg/day) for over 200 mechanically ventilated children 1 month through 12 years of age.
CO-PI: Torrey Baines, MD; Charlene Pringle, CPNP/AC-PC, FCCM
Publications:
- Brown, A. M., Irving, S. Y., Pringle, C., Allen, C., Brown, M. F., Nett, S., Singleton, M. N., Mikhailov, T. A., Madsen, E., Srinivasan, V., Anthony, H., Forbes, M. L., & the NutriNet and Pediatric Acute Lung Injury and Sepsis Investigators (PALISI) Network (2022). Bolus gastric feeds improve nutrition delivery to mechanically ventilated pediatric medical patients: Results of the COntinuous vs BOlus multicenter trial. JPEN. Journal of parenteral and enteral nutrition, 46(5), 1011–1021. https://doi.org/10.1002/jpen.2305
Continuous Albuterol (FM vs HFNC)
Single center observational study comparing outcomes of high flow nasal cannula and face mask for continuous albuterol delivery and association with length of stay, asthma scores, and need for escalation of therapy.
CO-PI: Nekaiya Jacobs, MD; Jennifer Munoz, MD
Publications:
- Jacobs, Nekaiya; Pareja, Jennifer Munoz; Samraj, Ravi Shankar; Avery, Leslie; Abu-Hasan, Mutasim; Keith, Bahareh; Fowler, Justin; Lucas, Judith. 1171: FACE MASK VERSUS HIGH-FLOW OXYGEN DELIVERY OF CONTINUOUS ALBUTEROL IN STATUS ASTHMATICUS. Critical Care Medicine 46(1):p 569, January 2018. | DOI: 10.1097/01.ccm.0000529176.67087.c1
Thenar tissue oxygenation (StO2): A non-invasive surrogate marker for central venous oxygen saturation.
Study comparing thenar tissue oxygenation device with traditional central venous oxygen saturations in critically ill children.
PI: Ravi Samraj
Publications:
- Samraj, R. S., Kerrigan, M., Mejia, M., Wilson, L., Fudge, J. C., Vyas, H. V., & Gupta, D. (2019). Thenar Muscle Oxygen Saturation Levels: A Surrogate for Central Venous Oxygen Saturation?. Clinical pediatrics, 58(5), 528–533. https://doi.org/10.1177/0009922819832094
- Samraj, R. S., Lopez-Colon, D., Kerrigan, M., Fricker, F. J., Pietra, B. A., Bleiweis, M., & Gupta, D. (2019). Thenar Muscle Oxygen Saturation Using Vascular Occlusion Test: A Novel Technique to Study Microcirculatory Abnormalities in Pediatric Heart Failure Patients. Pediatric cardiology, 40(6), 1151–1158. https://doi.org/10.1007/s00246-019-02118-y
PICU/PCICU Delirium
Single center, CAPD scoring for up to 7 days on most PICU and PCICU patients to define prevalence of delirium in our patient population.
CO-PI: Molly Mcgetrick, MD; Jennifer Munoz, MD
Publications:
- McGetrick, M. E., Lach, C., Mullen, J. E., & Munoz-Pareja, J. C. (2019). Assessing Nursing and Pediatric Resident Understanding of Delirium in the Pediatric Intensive Care Unit. Critical care nursing clinics of North America, 31(4), 481–488. https://doi.org/10.1016/j.cnc.2019.07.003
NPO/NIV (Nutritional practices and outcomes in non-invasive ventilation)
Multicenter (>80 children’s hospitals) period prevalence study evaluation nutiritional practices and patient outcomes across global regions for enteral and parenteral nutrition for infants and children initiated on NIV (BiPAP, CPAP, HFNC) for six 7 day study periods over 2017 and 2018.
Site PI: Charlene Pringle, CPNP/AC-PC, FCCM
ICARE (The Interdisciplinary Cardiac Arrest Research Review)
PI: Leslie Avery, MD
Publications:
- Gul, S. S., Cohen, S. A., Avery, K. L., Balakrishnan, M. P., Balu, R., Chowdhury, M. A. B., Crabb, D., Huesgen, K. W., Hwang, C. W., Maciel, C. B., Murphy, T. W., Han, F., Becker, T. K., & Interdisciplinary Cardiac Arrest Research Review ICARE group (2020). Cardiac arrest: An interdisciplinary review of the literature from 2018. Resuscitation, 148, 66–82. https://doi.org/10.1016/j.resuscitation.2019.12.030
- Murphy, T. W., Cohen, S. A., Avery, K. L., Balakrishnan, M. P., Balu, R., Chowdhury, M. A. B., Crabb, D. B., Huesgen, K. W., Hwang, C. W., Maciel, C. B., Gul, S. S., Han, F., Becker, T. K., & Interdisciplinary Cardiac Arrest Research Review (ICARE) group (2020). Cardiac arrest: An interdisciplinary scoping review of the literature from 2019. Resuscitation plus, 4, 100037. https://doi.org/10.1016/j.resplu.2020.100037