Completed Research Projects

Clinical Course Comparison of Children with Acute Respiratory Failure Secondary to COVID-19 and Viral Infection compared to Viral Infection Alone

Multicentric chart review study

PI: Krystyn Linville


Hemodynamic profile and efficacy on ICP management of ketamine vs propofol or midazolam for children with severe TBI

Multicentric chart review study.

PI: Charlene Pringle,  CPNP/AC-PC, FCCM (Joy fellowship project)


PERSEVERE

Genomic analysis of pediatric systemic inflammatory response syndrome

Site PI: Torrey Baines, MD

Publications:


Safety of extended propofol infusion in critically ill pediatric patients

Multicentric chart review study exploring safety of propofol infusions greater than 48 hours duration

PI: Charlene Pringle,  CPNP/AC-PC, FCCM (Moas fellowship project)

Publications:


Post-extubation dysphagia in children after mechanical ventilatory support

PI: Emily Plowman and Desiree Machado (Wang fellow project)


Death One Hour After Terminal Extubation (DONATE) Study

PI: Charlene Pringle,  CPNP/AC-PC, FCCM

Publications:


pBDCA (Validation of the Brain Death after out of hospital Cardiac Arrest score in children).

PI: Charlene Pringle,  CPNP/AC-PC, FCCM

Publications:


Incidence of air leak syndrome in SARS-CoV-2 in pediatrics

PI: Charlene Pringle,  CPNP/AC-PC, FCCM (Cardenas FELLOWSHIP PROJECT)

Publications:


Clinical changes in bronchiolitis after easing COVID-19 precautions

PI: Leslie Avery, MD (Cardenas fellowship project)

Publications:


Tethered liquid perfluorocarbon (TLP) surface coating for ECMO tubing, In-vitro model using human blood

PI: Giles Peek (Vazquez-Colon fellow project)


High-Fidelity Simulation Training for Parents of Medically Complex Children

Single-center, non-randomized prospective trial implementing simulation training for parents who will be discharged from the PICU with a child with a new tracheostomy.

PI: William Bortcosh


Peds PRES

Large case series of pediatric patients with hypertensive encephalopathy aiming to better describe risk factors and correlations.

PI: Charlene Pringle,  CPNP/AC-PC, FCCM | Sub-I: Manuel Viamonte

Publications:


ABC PICU (Age of Blood in Children in Pediatric Intensive Care Units)

Multicenter (>40 children’s hospitals) randomized clinical trial comparing the clinical consequences of RBC storage duration in 1538 critically ill children.

CO-PI: Leslie Avery, MD; Peter Pelletier, MD

Publications:


COBO2 (Continuous vs BOlus Nasogastric Feeding in Mechanically Ventilated Pediatric Patients 2

Multicenter (7 children’s hospitals) randomized clinical trial comparing continuous versus bolus gastric feeding modes for timing and delivery of prescribed energy (kcal/kg/day) and protein (g/kg/day) for over 200 mechanically ventilated children 1 month through 12 years of age.

CO-PI: Torrey Baines, MD; Charlene Pringle,  CPNP/AC-PC, FCCM

Publications:


Continuous Albuterol (FM vs HFNC)

Single center observational study comparing outcomes of high flow nasal cannula and face mask for continuous albuterol delivery and association with length of stay, asthma scores, and need for escalation of therapy.

CO-PI: Nekaiya Jacobs, MD; Jennifer Munoz, MD

Publications:


Thenar tissue oxygenation (StO2): A non-invasive surrogate marker for central venous oxygen saturation.

Study comparing thenar tissue oxygenation device with traditional central venous oxygen saturations in critically ill children.

PI: Ravi Samraj

Publications:


PICU/PCICU Delirium

Single center, CAPD scoring for up to 7 days on most PICU and PCICU patients to define prevalence of delirium in our patient population.

CO-PI: Molly Mcgetrick, MD; Jennifer Munoz, MD

Publications:


NPO/NIV (Nutritional practices and outcomes in non-invasive ventilation)

Multicenter (>80 children’s hospitals) period prevalence study evaluation nutiritional practices and patient outcomes across global regions for enteral and parenteral nutrition for infants and children initiated on NIV (BiPAP, CPAP, HFNC) for six 7 day study periods over 2017 and 2018.

Site PI: Charlene Pringle,  CPNP/AC-PC, FCCM


ICARE (The Interdisciplinary Cardiac Arrest Research Review)

PI: Leslie Avery, MD

Publications:

  • Gul, S. S., Cohen, S. A., Avery, K. L., Balakrishnan, M. P., Balu, R., Chowdhury, M. A. B., Crabb, D., Huesgen, K. W., Hwang, C. W., Maciel, C. B., Murphy, T. W., Han, F., Becker, T. K., & Interdisciplinary Cardiac Arrest Research Review ICARE group (2020). Cardiac arrest: An interdisciplinary review of the literature from 2018Resuscitation148, 66–82. https://doi.org/10.1016/j.resuscitation.2019.12.030
  • Murphy, T. W., Cohen, S. A., Avery, K. L., Balakrishnan, M. P., Balu, R., Chowdhury, M. A. B., Crabb, D. B., Huesgen, K. W., Hwang, C. W., Maciel, C. B., Gul, S. S., Han, F., Becker, T. K., & Interdisciplinary Cardiac Arrest Research Review (ICARE) group (2020). Cardiac arrest: An interdisciplinary scoping review of the literature from 2019Resuscitation plus4, 100037. https://doi.org/10.1016/j.resplu.2020.100037