Active Research Projects

ABC PICU (Age of Blood in Children in Pediatric Intensive Care Units)

CO-PI: Leslie Avery, MD; Peter Pelletier, MD
Multicenter (>40 children’s hospitals) randomized clinical trial comparing the clinical consequences of RBC storage duration in 1538 critically ill children.

COBO2 (Continuous vs BOlus Nasogastric Feeding in Mechanically Ventilated Pediatric Patients 2

CO-PI: Torrey Baines, MD; Charlene Leonard, APRN
Multicenter (7 children’s hospitals) randomized clinical trial comparing continuous versus bolus gastric feeding modes for timing and delivery of prescribed energy (kcal/kg/day) and protein (g/kg/day) for over 200 mechanically ventilated children 1 month through 12 years of age.

Continuous Albuterol (FM vs HFNC)

CO-PI: Nekaiya Jacobs, MD; Jennifer Munoz, MD
Single center observational study comparing outcomes of high flow nasal cannula and face mask for continuous albuterol delivery and association with length of stay, asthma scores, and need for escalation of therapy

Thenar tissue oxygenation (StO2): A non-invasive surrogate marker for central venous oxygen saturation.

PI: Ravi Samraj
Study comparing thenar tissue oxygenation device with traditional central venous oxygen saturations in critically ill children.


CO-PI: Molly Mcgetrick, MD; Jennifer Munoz, MD
Single center, CAPD scoring for up to 7 days on most PICU and PCICU patients to define prevalence of delirium in our patient population

PI: Charlene Leonard

Development and Validation of a Nutrition Screening Tool for Critically Ill Children

Multi-center phase II validation of a novel screening tool for malnutrition in critically ill children.

PI: Jennifer Munoz

DOSE trial: Dexmedetomidine Opioid Sparing Effect in Mechanically Ventilated Children

Multi-center RCT.

PI: Elizabeth Macari

LVK (LongVentKids study): Prolonged Mechanical Ventilation in Pediatric Intensive Care

Multi-center/PALISI period prevalence study about long term mechanical ventilation.

PI: Jennifer Munoz

Pediatric TBI Repository

The overall goal of this study is to create a pediatric TBI biorepository that will serve as a platform for a systematic, multimodal assessment of severity and outcome at the University of Florida.

PI: Jennifer Munoz

T-CF Testing for Autoimmune Disease

Identification of autoimmune central nervous system diseases via flow cytometry.

PI: Torrey Baines

PERSEVERE (Genomic analysis of pediatric systemic inflammatory response syndrome)

Multicenter study including patients 1 months to 10 years of age admitted to the PICU with SIRS or sepsis. The purpose of the study is to determine if outcomes in pediatric sepsis are influence by any specific genetic makeup of the individual.

PI: Charlene Leonard

NPO/NIV (Nutritional practices and outcomes in non-invasive ventilation)

Multicenter (>80 children’s hospitals) period prevalence study evaluation nutiritional practices and patient outcomes across global regions for enteral and parenteral nutrition for infants and children initiated on NIV (BiPAP, CPAP, HFNC) for six 7 day study periods over 2017 and 2018.

PI: Leslie Avery

PROSpect (PRone and OScillation PEdiatric Clinical Trial)

Multicenter (~50 PICUs) 2×2 factorial, response adaptive randomized clinical trial of supine/prone positioning and CMV/HFOV for pediatric patients with severe pARDS.

PI: Charlene Leonard | Sub-I: Manuel Viamonte


Large case series of pediatric patients with hypertensive encephalopathy aiming to better describe risk factors and correlations.

PI: Lara Nicolas | Sub-I: Mai Miyaji

Thenar Tissue Oxygenation for Pediatric Sepsis

Study examining vascular occlusion test and outcomes in pediatric sepsis.