Active Research Projects

site PI: Charlene Pringle

Development and Validation of a Nutrition Screening Tool for Critically Ill Children

Multi-center phase II validation of a novel screening tool for malnutrition in critically ill children.

PI: Kourtney Guthrie

Pediatric TBI Repository

The overall goal of this study is to create a pediatric TBI biorepository that will serve as a platform for a systematic, multimodal assessment of severity and outcome at the University of Florida.

site PI: Torrey Baines

PERSEVERE (Genomic analysis of pediatric systemic inflammatory response syndrome)

Multicenter study including patients 1 months to 10 years of age admitted to the PICU with SIRS or sepsis. The purpose of the study is to determine if outcomes in pediatric sepsis are influence by any specific genetic makeup of the individual.


NIV Dex EN (Impact of enteral nutrition on dexmedetomidine usage in critically ill children requiring NIV)

Study now expanded to include 14 other children’s hospitals exploring sedation requirements of children acutely supported with NIV with and without enteral nutrition.

Site PI: Leslie Avery

ICARE (The Interdisciplinary Cardiac Arrest Research Review)

The Interdisciplinary Cardiac Arrest Research Review (ICARE) group was formed in 2018 to conduct a systematic annual search of peer-reviewed literature relevant to cardiac arrest (CA). The goals of the review are to illustrate best practices and help reduce knowledge silos by disseminating clinically relevant advances in the field of CA across disciplines.

PI: Kourtney Guthrie

NIDAI test: Characterization of the peripheral immunologic response in neuroimmune diseases.

PI: Krystyn Linville

Clinical Course Comparison of Children with Acute Respiratory Failure Secondary to COVID-19 and Viral Infection compared to Viral Infection Alone

Multicentric chart review study

PI: Charlene Pringle (Joy fellowship project)

Hemodynamic profile and efficacy on ICP management of ketamine vs propofol or midazolam for children with severe TBI

Multicentric chart review study.

Site PI: Leslie Avery


Multicenter RCT to establish the efficacy of cooling and the optimal duration of induced hypothermia for neuroprotection in pediatric comatose survivors of cardiac arrest.

Site PI: Charlene Pringle

PROBE pediatric registry of brain death practices

Site PI: Charlene Pringle

Massive Bleeding in Children with Cancer or Hematopoietic Stem Cell Transplant (MATIC Ca)

Multicentric retrospective descriptive study from PALISI BloodNet.

Site PI: Kourtney Guthrie

ARDS in Children and ECMO Initiation Strategies Impact on Neuro Development (ASCEND)

Multicentric prospective observational study

PI: Lara Nicolas

Performance of the nSOFA score compared to the pSOFA score in neonates

PI: Lara Nicolas

Pediatric Sequential Organ Failure Assessment and Outcomes in burns

PI: Lara Nicolas

Pediatric Sequential Organ Failure Assessment and Outcomes in pediatric traumas and TBIs

PI: Lara Nicolas (Castillo fellowship project)

Pediatric Sequential Organ Failure Assessment and Vasoactive Inotropic Score: Assessment and outcomes in pediatric sepsis

Site PI: Jose Cardenas

Association of hyperchloremia and acute kidney injury in pediatric patients with severe TBI

Multicentric retrospective cohort study from PNCRG.

Site PI: Natalia Martinez-Schlurmann

Bronchiolitis and critical care outcomes with noninvasive respiratory support (BACON 2.0)

Period prevalence observational study from PALISI.